New Benzoxazole Derivatives as Antiprotozoal Agents: In Silico Studies, Synthesis, and Biological Evaluation

Table 1

Antimalarial action of the potential derivatives.

Compound	P. falciparum, D6		P. falciparum, W2		VERO, IC50 (µM)
	IC50 (µM)	SI	IC50 (µM)	SI
4a	9.1	>1.1	10	>1	>10.1
5a	5.1	1.2	2.2	2.8	6.3
6d	5.5	0.8	4.1	1.1	4.7
Chloroquine	0.03	—	0.31	—	NC
Artemisinin	0.02	—	0.01	—	NC

NC: not cytotoxic; W2, chloroquine-resistant strain; D6, chloroquine-susceptible strain; selectivity index (SI) (IC₅₀ for Vero cells/IC₅₀ for P. falciparum).