Schiff Bases of Isatin and Adamantane-1-Carbohydrazide: Synthesis, Characterization and Anticonvulsant Activity

Table 2

Effect of the synthesized compounds on latency and duration of PTZ-induced seizure.

Compound	Dose (mg/kg)	Time (sec.) of the latency of convulsions (MEN ± SEM)	Duration (sec.) of convulsion (MEN ± SEM)
Methylcellulose	0.004 mL/g	280.5 ± 54.06	116 ± 12.99
Phenobarbitone	30	467.5 ± 56.41	58 ±
	100	Nil	Nil
18	30	313.3 ± 84.47	34.25 ± 4.80
	100	780 ± 243.7	62.50 ± 9.77
19	30	539.3 ± 169.8	95.00 ± 27.54
	100	494.8 ± 8.179	82.75 ± 13.07
20	30	600.0 ± 73.48	115.0 ± 5.00
	100	675.0 ± 137.2	77.5 ± 10.31
21	30	429.0 ± 94.19	64.50 ± 8.95
	100	432.5 ± 124.7	55.00 ± 5.00
22	30	513.5 ± 70.89	46.00 ± 8.495
	100	396.8 ± 78.04	45.00 ± 0.00
23	30	1263 ± 501.2	45.75 ± 9.903
	100	329.8 ± 23.01	64.25 ± 12.17

Data analyzed by one-way ANOVA followed by Dunnett’s test (n = 4); , , and when compared with the control group.