Schiff Bases of Isatin and Adamantane-1-Carbohydrazide: Synthesis, Characterization and Anticonvulsant Activity

Table 3

Effect of synthesized compounds on neurological signs of PTZ-induced seizure 1 hour after induction.

Compound	Dose (mg\kg)	Myoclonic jerks	S-shape in the tail	Upright position	Head nodding	Loss of postural control	Muscle flaccid	A tonic or clonic
Methyl cellulose 5%	0.004 mL/g	+++	+++	++	+++	+++	+++	+++
Phenobarbital	30	++	++	+	+	++	++	+
	100	Nil	Nil	Nil	Nil	Nil	Nil	Nil
18	30	++	++	Nil	Nil	++	+	++
	100	Nil	+	+	Nil	+	+	+++
19	30	++	++	+	++	++	++	++++
	100	++	++	++	+	++	+	+++
20	30	+++	+	Nil	+++	++	++	++
	100	+++	++	+	+++	++	++	++
21	30	++	++	+	Nil	+	+	++
	100	++	++	+	Nil	++	+	++
22	30	+	++	+	+	++	++	+
	100	++	++	++	+	++	+++	++
23	30	++	Nil	Nil	+	+	+	+
	100	++	+	+	+	+	Nil	Nil

The severity of the neurological signs: ⁺mild, ⁺⁺moderate, and ⁺⁺⁺severe.