Research Article
Schiff Bases of Isatin and Adamantane-1-Carbohydrazide: Synthesis, Characterization and Anticonvulsant Activity
Table 3
Effect of synthesized compounds on neurological signs
of PTZ-induced seizure 1 hour after induction.
| Compound | Dose (mg\kg) | Myoclonic jerks | S-shape in the tail | Upright position | Head nodding | Loss of postural control | Muscle flaccid | A tonic or clonic |
| Methyl cellulose 5% | 0.004 mL/g | +++ | +++ | ++ | +++ | +++ | +++ | +++ | Phenobarbital | 30 | ++ | ++ | + | + | ++ | ++ | + | 100 | Nil | Nil | Nil | Nil | Nil | Nil | Nil |
| 18 | 30 | ++ | ++ | Nil | Nil | ++ | + | ++ | 100 | Nil | + | + | Nil | + | + | +++ |
| 19 | 30 | ++ | ++ | + | ++ | ++ | ++ | ++++ | 100 | ++ | ++ | ++ | + | ++ | + | +++ |
| 20 | 30 | +++ | + | Nil | +++ | ++ | ++ | ++ | 100 | +++ | ++ | + | +++ | ++ | ++ | ++ |
| 21 | 30 | ++ | ++ | + | Nil | + | + | ++ | 100 | ++ | ++ | + | Nil | ++ | + | ++ |
| 22 | 30 | + | ++ | + | + | ++ | ++ | + | 100 | ++ | ++ | ++ | + | ++ | +++ | ++ |
| 23 | 30 | ++ | Nil | Nil | + | + | + | + | 100 | ++ | + | + | + | + | Nil | Nil |
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The severity of the neurological signs: +mild, ++moderate, and +++severe. |