Schiff Bases of Isatin and Adamantane-1-Carbohydrazide: Synthesis, Characterization and Anticonvulsant Activity

Table 4

Neurotoxicity of synthesized compounds during 1 hour of induction.

Compound	Dose (mg\kg)	Circular or zigzag gait	Abnormal spread of legs	Abnormal posture	Tremor	Lack of exploratory behavior	Somnolence or sleep	Stupor or catalepsy
Methyl cellulose	—	+	++	++	++	Nil	Nil	Nil
Phenobarbital	30	+	++	+	+	Nil	1 h	Nil
	100	Nil	Nil	Nil	Nil	Nil	1 h	Nil
18	30	Nil	++	+	++	+	1 h	Nil
	100	Nil	+	+	++	+	1 h	Nil
19	30	+	++	++	++	++	1 h	++
	100	Nil	++	++	++	+	1 h	++
20	30	Nil	+	+	+	++	1 h	Nil
	100	++	++	+	+	1 h	1 h	1 h
21	30	Nil	+	+	+	+	1 h	+
	100	+	+	+	+	+	1 h	Nil
22	30	Nil	++	++	++	Nil	1 h	Nil
	100	Nil	++	++	++	Nil	1 h	Nil
23	30	Nil	+	+	++	Nil	1 h	1 h
	100	Nil	Nil	+	+	+	1 h	1 h

The severity of the neurotoxicity signs: ⁺mild, ⁺⁺moderate, and ⁺⁺⁺severe.