Research Article
Schiff Bases of Isatin and Adamantane-1-Carbohydrazide: Synthesis, Characterization and Anticonvulsant Activity
Table 4
Neurotoxicity
of synthesized compounds during 1 hour of induction.
| Compound | Dose (mg\kg) | Circular or zigzag gait | Abnormal spread of legs | Abnormal posture | Tremor | Lack of exploratory behavior | Somnolence or sleep | Stupor or catalepsy |
| Methyl cellulose | — | + | ++ | ++ | ++ | Nil | Nil | Nil | Phenobarbital | 30 | + | ++ | + | + | Nil | 1 h | Nil | 100 | Nil | Nil | Nil | Nil | Nil | 1 h | Nil |
| 18 | 30 | Nil | ++ | + | ++ | + | 1 h | Nil | 100 | Nil | + | + | ++ | + | 1 h | Nil |
| 19 | 30 | + | ++ | ++ | ++ | ++ | 1 h | ++ | 100 | Nil | ++ | ++ | ++ | + | 1 h | ++ |
| 20 | 30 | Nil | + | + | + | ++ | 1 h | Nil | 100 | ++ | ++ | + | + | 1 h | 1 h | 1 h |
| 21 | 30 | Nil | + | + | + | + | 1 h | + | 100 | + | + | + | + | + | 1 h | Nil |
| 22 | 30 | Nil | ++ | ++ | ++ | Nil | 1 h | Nil | 100 | Nil | ++ | ++ | ++ | Nil | 1 h | Nil |
| 23 | 30 | Nil | + | + | ++ | Nil | 1 h | 1 h | 100 | Nil | Nil | + | + | + | 1 h | 1 h |
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The severity of the neurotoxicity signs: +mild, ++moderate, and +++severe. |