Transitioning from Oxime to the Next Potential Organophosphorus Poisoning Therapy Using Enzymes

Table 1

Validated decontamination and detoxification approaches using enzymes.

Authors	Enzyme and matrix for immobilization	Application
Caldwell and Raushel, 1991	PTE from Pseudomonas diminuta onto the trityl agarose matrix	Detoxify various OPs with higher affinity towards paraoxon
Raynes et al., 2011	PTE from Pseudomonas diminuta using amyloid fibrils generated from insulin and crystallin	Detoxify various OPs with higher affinity towards paraoxon
Gao et al., 2014	OpdA from using covalent immobilization onto polyester textiles	Effectively degrades organophosphate pesticides and environmental remediation (decontamination)
Suthiwangcharoen and Nagarajan, 2014	PTE from Pseudomonas diminuta using amphiphilic block copolymer	Detoxify various OPs with higher affinity towards paraoxon
Mechrez et al., 2014	PTE from D. radiodurans onto carbon nanotube paper	Environmental remediation of biomedical devices (decontamination)