Synthesis, Spectral Characterization, and In Vitro Cytotoxicity of Some Fe(III) Complexes Bearing Unsymmetrical Salen-Type Ligands Derived from 2-Hydroxynaphthaldehyde and Substituted Salicylaldehydes

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td class="align_left" rowspan="2">Complex</td><td class="align_center" colspan="3">IC<sub>50</sub> (<i>μ</i>M)</td></tr><tr class="thead"><td class="align_center">KB</td><td class="align_center">HepG2</td><td class="align_center">HEK-293</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td class="align_left">H<sub>2</sub>L1</td><td class="align_center">&gt;100</td><td class="align_center">51.48 ± 2.71</td><td class="align_center">nd</td></tr><tr><td class="align_left">[Fe(III)L1Cl]</td><td class="align_center">0.81 ± 0.08</td><td class="align_center">3.18 ± 0.19</td><td class="align_center">9.33 ± 0.17</td></tr><tr><td class="align_left">[Fe(III)L2Cl]</td><td class="align_center">3.53 ± 0.17</td><td class="align_center">25.45 ± 1.21</td><td class="align_center">nd</td></tr><tr><td class="align_left">[Fe(III)L3Cl]</td><td class="align_center">10.97 ± 0.65</td><td class="align_center">63.31 ± 2.55</td><td class="align_center">nd</td></tr><tr><td class="align_left">[Fe(III)L4Cl]</td><td class="align_center">14.14 ± 0.58</td><td class="align_center">56.53 ± 2.25</td><td class="align_center">nd</td></tr><tr><td class="align_left">[Fe(III)L5Cl]</td><td class="align_center">8.31 ± 0.43</td><td class="align_center">28.31 ± 1.47</td><td class="align_center">nd</td></tr><tr><td class="align_left">[Fe(III)L6Cl]</td><td class="align_center">2.61 ± 0.10</td><td class="align_center">1.87 ± 0.08</td><td class="align_center">6.34 ± 0.10</td></tr><tr><td class="align_left">Ellipticine</td><td class="align_center">1.14 <b>±</b> 0.08</td><td class="align_center">2.11 <b>±</b> 0.16</td><td class="align_center">6.69 <b>±</b> 0.32</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td><div>nd: not determined.<br/></div></td></tr></table>

<div><i>In vitro</i> cytotoxicity of the unsymmetrical salen-type Fe(III) complexes.</div>

Journal of Chemistry

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Table 1

Table 1: Synthesis, Spectral Characterization, and In Vitro Cytotoxicity of Some Fe(III) Complexes Bearing Unsymmetrical Salen-Type Ligands Derived from 2-Hydroxynaphthaldehyde and Substituted Salicylaldehydes 

Table 1 | Synthesis, Spectral Characterization, and In Vitro Cytotoxicity of Some Fe(III) Complexes Bearing Unsymmetrical Salen-Type Ligands Derived from 2-Hydroxynaphthaldehyde and Substituted Salicylaldehydes 