Substituted-Amidine Functionalized Monocyclic β-Lactams: Synthesis and In Vitro Antibacterial Profile

Scheme 2

Synthesis of compounds 14a–e. Reagents and conditions: (a) 10, EtOH-CHCl₃, rt, 71–87%; (b) 12a, HOBT, DCC, NaHCO₃, DMF, 0°C – rt, 41–88%; (c) TFA, CH₂Cl₂, 0°C – rt, 7–15%.