3,5-Dinitrobenzoate and 3,5-Dinitrobenzamide Derivatives: Mechanistic, Antifungal, and In Silico Studies

Table 2

MIC values in (µg/mL) and (mM) of esters 2 and 3 in the absence and presence of sorbitol (0.8 M) and ergosterol against Candida albicans.

Compound	Concentration (µg/mL)/(mM)	Candida albicans (CBS 562)		Candida albicans (CBS 562)
		Without sorbitol (µg/mL)/(mM)	With sorbitol (µg/mL)/(mM)	Without ergosterol (µg/mL)/(mM)	With ergosterol (µg/mL)/(mM)
2	1000/4.16	−	−	−	−
	500/2.08	−	−	−	−
	250/1.04	−	−	−	−
	125/0.52	−	−	−	+
	62.5/0.26	+	+	+	+
	31.25/0.13	+	+	+	+
3	1000/3.92	−	−	−	−
	500/1.96	−	−	−	+
	250/0.98	−	−	−	+
	125/0.49	+	+	+	+
	62.5/0.24	+	+	+	+
	31.25/0.12	+	+	+	+
Nystatin	120/0.128			−	−
	60/0.064			−	−
	30/0.032			−	+
	15/0.016			−	+
	7.5/0.008			−	+
	3.75/0.0040			−	+
	1.87/0.002			+	+
	0.93/0.001			+	+
Caspofungin	1/0.000896	−	−
	0.5/0.000448	−	−
	0.25/0.000224	−	+
	0.125/0.000112	−	+
	0.0625/0.000056	−	+
	0.031/0.000028	−	+
	0.015/0.000014	+	+

(+) indicates growth of the microorganism. (−): no growth of the microorganism.