Anti-Diabetic Effects of Cucurbitacins from Ibervillea lindheimeri on Induced Mouse Diabetes

Figure 7

Binding of compounds 1 and 2 to AKT and AMPK. (a) Binding of compounds 1 and 2 to the ATP binding site of AKT showing inhibitor G98, and compounds 1 and 2 bound. (b) Binding of compounds 1 and 2 to the cystathionine β-synthetase (CBS) sites CBS1, CBS3, and CBS4 of AMPK. Panels show the residues of the active site of the enzymes located within 4 Å of compounds 1 and 2. Amino acids (colored in green) and compounds 1 (colored in pink) and 2 (colored in magenta) are shown as sticks. For AKT, the inhibitor G98 is shown in cyan, while for AMPK, ADP bound to CBS1 and AMP bound to CBS3 and CBS4 are shown in yellow. H-bonds of the compounds with residues of the binding site of the enzymes are indicated by orange dashed lines. The figure was drawn with PyMOL version 2.1.0 (Schrödinger, LLC; https://sourceforge.net/p/pymol).

(a)

(b)