Evaluation of 3,5-Diphenyl-2-Pyrazolines for Antimitotic Activity by Inhibition of Tubulin Polymerization

Table 1

The half-maximal cell growth inhibitory concentrations (GI₅₀) of 3,5-diphenyl-2-pyrazolines obtained by the clonogenic long-term survival assay of HCT116 human colon cancer cells.

Derivatives	GI50/μM	Standard deviation
1	0.09	0.00
2	0.94	0.00
3	0.93	0.00
4	0.09	0.00
5	9.74	0.06
6	1.47	0.03
7	0.97	0.00
8	6.07	0.12
9	2.11	0.04
10	0.80	0.00
11	2.01	0.06
12	1.84	0.01
13	0.95	0.00
14	0.98	0.00
15	11.94	0.24
16	0.98	0.00
17	Not detected	—
18	Not detected	—
19	14.82	0.23