A Comprehensive Review on Distribution, Pharmacological Properties, and Mechanisms of Action of Sesamin

Table 5

Effects of sesamin on hypertension.

Experimental model	Dosage	Administration mode	Administration duration	Mechanism of action	References
Pulmonary hypertensive rats	50, 100 mg/kg	Injection	4 weeks	The RVSP and mPAP of rats decreased significantly; the expressions of α-SMA and collagen I in pulmonary artery decreased	[93]
Spontaneously hypertensive rats	40, 80, 160 mg/kg	Intragastric administration	16 weeks	SBP, DBP, and MAP were significantly reduced; the content of NO in the aorta and the expression of eNOS mRNA increased	[94]
DOCA salt-sensitive hypertensive rats	10 g/kg	Orally	5 weeks	The systolic blood pressure and the expression of p22phox, gp91phox, and Nox1 decreased	[89]
Two-kidney one-clip hypertensive rats	60, 120 mg/kg	Orally	8 weeks	The systolic blood pressure decreased by 11% (60 mg/kg) and 17% (120 mg/kg)	[95]
Streptozotocin-induced diabetic rat model	50, 100, 200 mg/kg	Orally	4 weeks	Increased systolic and diastolic blood pressure: 50 mg (17/8.2 mmHg), 100 mg (37.8/14.7 mmHg), and 200 mg (38.6/17.5 mmHg)	[96]