An <i>In Silico</i> Study of the Interactions of Alkaloids from <i>Cryptolepis sanguinolenta</i> with <i>Plasmodium falciparum</i> Dihydrofolate Reductase and Dihydroorotate Dehydrogenase

<div>3D X-ray crystal structures of ligands in the DHFR variants. (a) Pyrimethamine in the wild-type DHFR; (b) pyrimethamine in the double mutant DHFR; (c) WR99210 in the quadruple mutant DHFR.</div>

Journal of Chemistry

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Figure 4

Figure 4: An <i>In Silico</i> Study of the Interactions of Alkaloids from <i>Cryptolepis sanguinolenta</i> with <i>Plasmodium falciparum</i> Dihydrofolate Reductase and Dihydroorotate Dehydrogenase 

Figure 4 | An In Silico Study of the Interactions of Alkaloids from Cryptolepis sanguinolenta with Plasmodium falciparum Dihydrofolate Reductase and Dihydroorotate Dehydrogenase 