Manganese Schiff Base Complexes, Crystallographic Studies, Anticancer Activities, and Molecular Docking

Table 11

Anticancer effects of Schiff base ligand and its metal complexes in % cell inhibition at 100 μg/ml concentration.

Samples	% cell inhibition	Surviving fraction (MCF-7)					IC50 (μg/ml)
		0.0	5.0	12.5	25	50
H2L	64						—
[Cd(H2L) (H2O)Cl2]	64						—
[Cr(H2L)(H2O)2Cl]Cl2·2H2O	64						—
[Cu(H2L)Cl]Cl·2H2O	70	1	1	0.73	0.33	0.31	19.6
[Fe(H2L)(H2O)2Cl]Cl2	75	1	0.88	0.71	0.64	0.25	33
[Mn(H2L)(H2O)2Cl]Cl·2H2O	72	1	0.85	0.73	0.51	0.33	26
[Ni(H2L)(H2O)]Cl2·4H2O	75	1	0.88	0.81	0.62	0.3	34
[Zn(H2L)(H2O)Cl2]·2H2O	67						—