Manganese Schiff Base Complexes, Crystallographic Studies, Anticancer Activities, and Molecular Docking

Table 2

The IC₅₀ (μM) results for the in vitro cytotoxic activities for three compounds screened against lung cancer (A549), cervical carcinoma (HeLa), and breast cancer MDA-MB-231 cell lines.

Metal complex	A549	HeLa	MDA-MB-231
[Mn(ONO-(S)L1)2]	34.63 ± 1.54	38.73 ± 1.59	46.85 ± 1.67
[Cu(ONO-(R)L2)]4.2CH3OH	29.68 ± 1.47	17.94 ± 1.25	6.20 ± 0.79
[Mn3(ONO-(S)L3)4(OAc)4(H2O)2][Mn3(S-L3)4(OAc)4(H2O)2]	21.91 ± 1.36	10.54 ± 1.02	18.42 ± 1.27
Cisplatin	>60	>60	>60

A549, lung cancer cell line; HeLa, cervical carcinoma cell line; MDA-MB-231, breast cancer cell line; cisplatin, positive control.