Manganese Schiff Base Complexes, Crystallographic Studies, Anticancer Activities, and Molecular Docking

Table 6

The IC₅₀ results for the in vitro cytotoxic activities of ligand, Cu(II) complex, and Mn(II) complex and 5-FU screened against six cancer cell lines.

Cell lines	IC50 values (μM)
	Ligand	Cu(II) complex	Mn(II) complex	5-FU
MCF-7	>1000	43.4	273.6	58.44
DLD-1	219.4	142.9	193.8	39.34
DU-145	177.2	93.5	182.9	50.22
ECC-1	386.9	100	304.8	34.4
HEK293	327.8	398.8	373.1	24.33
MCF-7	>1000	43.4	273.6	58.44
MDA-MB231	176.6	129	187.8	62.33
PC3	310.5	63.2	117.3	55.44

Light red, low activity; yellow, moderate activity; green, high activity.