Research Article
Validated UPLC-MS/MS Method for Determination of Futibatinib and Its Pharmacokinetics in Beagle Dogs
Table 1
Precision and accuracy of futibatinib in the beagle plasma (n = 6).
| | Added (ng/mL) | Intraday | Interday | | Found (ng/mL) | RSD (%) | RE (%) | Found (ng/mL) | RSD (%) | RE (%) |
| | 0.5 | 0.51 ± 0.02 | 4.26 | 1.33 | 0.51 ± 0.01 | 2.34 | 1.11 | | 1.0 | 1.02 ± 0.06 | 6.00 | 1.50 | 0.99 ± 0.02 | 1.62 | −0.67 | | 10 | 9.61 ± 1.03 | 10.70 | −3.87 | 10.33 ± 0.33 | 3.22 | 3.28 | | 75 | 72.71 ± 5.98 | 8.22 | −3.06 | 74.68 ± 1.82 | 2.44 | −0.43 |
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