Research Article
Phytochemical Investigation of Egyptian Riverhemp: A Potential Source of Antileukemic Metabolites
Table 2
IC50 [μM] of active isolated compounds against selected transcription factor signaling pathways in HeLa cells
| | Compound no. | Stat 3/IL-6 | Smad/TGF-β | AP-1/PMA | NF-kB/PMA | E2F/PMA | Myc/PMA | ETS/PMA | Notch/PMA | FOXO | Wnt/m-Wnt-3a | Hedgehog /PMA | pTK | miR-21 | K-Ras | AhR |
| | 21 | 13.9 | 9.5 | 20.9 | 21.3 | 10.5 | 15.2 | 11.4 | 11.3 | ND | 4.6 | 14.4 | ND | 21.4 | 23.1 | ND | | 22 | 17.5 | 3.8 | 22.2 | 32.3 | ND | 18.3 | 18.9 | 21.0 | ND | 3.8 | 20.1 | ND | 25.8 | 26.3 | ND | | 24 | 15.9 | 13.9 | 16.3 | 18.8 | ND | 14.4 | 16.5 | 17.9 | ND | 13.5 | 16.9 | ND | 18.2 | 15.5 | 17.5 | | 34 | 6.9 | 5.8 | 7.0 | 6.3 | 5.3 | 5.9 | 6.8 | 6.5 | ND | 6.70 | 7.40 | 7.30 | 8.00 | NA | ND |
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