Research Article
In Silico, SwissADME, and DFT Studies of Newly Synthesized Oxindole Derivatives Followed by Antioxidant Studies
Table 5
Drug-likeness scores and medicinal chemistry properties of oxindoles (C-1 and C-2).
| Ligands | Drug-likeness rules | Medicinal chemistry | Lipinski | Ghose | Veber | Egan | Muegge | PAINS | Brenk | Lead likeness | Synthetic accessibility |
| C-1 | Yes | Yes | Yes | Yes | Yes | 0 alert | 2 alerts: michael_acceptor-, stilbene | No; 1 violation: XLOGP3 > 3.5 | 2.52 | C-2 | Yes | Yes | Yes | Yes | Yes | 0 alert | 2 alerts: michael_acceptor_1, stilbene | No; 1 violation: XLOGP3 > 3.5 | 2.55 |
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