Research Article
In Silico, SwissADME, and DFT Studies of Newly Synthesized Oxindole Derivatives Followed by Antioxidant Studies
Table 8
Results of compounds (C-1 and C-2) for DPPH scavenging activity.
| Compounds | Concentrations (μM) | Findings | % Inhibition | IC50 (μM) |
| Control | | 0.706 ± 0.02845 | | |
| Compound 1 | 1000 | 0.066 ± 0.00115 | 91 | 37.390 | 500 | 0.09833 ± 0.00203 | 86 | 250 | 0.151 ± 0.00524 | 79 | 125 | 0.24067 ± 0.01784 | 66 | 62.5 | 0.28533 ± 0.01419 | 60 |
| Compound 2 | 1000 | 0.10 ± 0.00651 | 86 | 34.676 | 500 | 0.13466 ± 0.02577 | 81 | 250 | 0.191 ± 0.00681 | 73 | 125 | 0.25067 ± 0.01995 | 64 | 62.5 | 0.29 ± 0.05105 | 59 |
| Standard | 1000 | 0.05367 ± 0.00145 | 92 | 29.363 | 500 | 0.07467 ± 0.01586 | 89 | 250 | 0.143 ± 0.01539 | 80 | 125 | 0.207 ± 0.00436 | 71 | 62.5 | 0.263 ± 0.00961 | 63 |
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Inhibition percentages (%) and IC 50 values (mean ± SEM of n = 3) are used to present the results. < 0.05 significant; < 0.01 significant. |