Research Article
In Silico, SwissADME, and DFT Studies of Newly Synthesized Oxindole Derivatives Followed by Antioxidant Studies
Table 9
Results of compounds (C-1 and C-2) for ABTS scavenging activity.
| Compounds | Concentrations (μM) | Findings | % Inhibition | IC50 (μM) |
| Control | | 0.65333 ± 0.01453 | | |
| Compound 1 | 1000 | 0.08167 ± 0.00203 | 88 | 25.381 | 500 | 0.102 ± 0.00751 | 84 | 250 | 0.17133 ± 0.0109 | 74 | 125 | 0.20833 ± 0.00924 | 68 | 62.5 | 0.24133 ± 0.00328 | 63 |
| Compound 2 | 1000 | 0.09533 ± 0.00176 | 85 | 33.706 | 500 | 0.14 ± 0.02183 | 79 | 250 | 0.198 ± 0.0168 | 70 | 125 | 0.23267 ± 0.00639 | 64 | 62.5 | 0.267 ± 0.01332 | 59 |
| Standard | 1000 | 0.048 ± 0.00208 | 93 | 26.522 | 500 | 0.0692 ± 0.0283 | 90 | 250 | 0.129 ± 0.00231 | 82 | 125 | 0.14313 ± 0.09187 | 78 | 62.5 | 0.23467 ± 0.00666 | 64 |
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Inhibition percentages (%) and IC 50 values (mean ± SEM of n = 3) are used to present the results. < 0.05; < 0.01. |