New Psychoactive Substances: Major Groups, Laboratory Testing Challenges, Public Health Concerns, and Community-Based Solutions

Table 3

Common 25-NB derivatives.

Common name	Chemical structure	R1	R	Chemical name	Cyc	References
25B-NB23DM		H	2,5-dimethoxy-4-bromo	N-(2,3-dimethoxybenzyl)-1-(2,5-dimethoxy-4-bromophenyl)-2-aminoethane	2,3-dimethoxyphenyl	[37, 38, 187]
25B-NBMD		H	2,5-dimethoxy-4-bromo	N-(2,3-methylenedioxybenzyl)-1-(2,5-dimethoxy-4-bromophenyl)-2-aminoethane	2,3-methylenedioxyphenyl	[187, 188]
25C-NBMD		H	2,5-dimethoxy-4-chloro	N-(2,3-methylenedioxybenzyl)-1-(2,5-dimethoxy-4-chlorophenyl)-2-aminoethane	2,3-methylenedioxyphenyl	[187, 189, 190]
25I-NBMD		H	2,5-dimethoxy-4-iodo	N-(2,3-methylenedioxybenzyl)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminoethane	2,3-methylenedioxyphenyl	[37, 38, 187–191]
25D-NBMD		H	2,5-dimethoxy-4-methyl	N-(2,3-methylenedioxybenzyl)-1-(2,5-dimethoxy-4-methylphenyl)-2-aminoethane	2,3-methylenedioxyphenyl	[38, 188, 189, 191]
25B-NB25DM		H	2,5-dimethoxy-4-bromo	N-(2,5-dimethoxybenzyl)-1-(2,5-dimethoxy-4-bromophenyl)-2-aminoethane	2,5-dimethoxyphenyl	[187, 188, 190]
25I-NBBr		H	2,5-dimethoxy-4-iodo	N-(2-bromobenzyl)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminoethane	2-bromophenyl	[187, 190]
25C-NBCl		H	2,5-dimethoxy-4-chloro	N-(2-chlorobenzyl)-1-(2,5-dimethoxy-4-chlorophenyl)-2-aminoethane	2-chlorophenyl	[187, 189]
Clobenzorex		methyl	H	N-(2-chlorobenzyl)-1-phenyl-2-aminopropane	2-chlorophenyl	[37, 38, 187–191]
25C-NBOEt		H	2,5-dimethoxy-4-chloro	N-(2-ethoxybenzyl)-1-(2,5-dimethoxy-4-chlorophenyl)-2-aminoethane	2-ethoxyphenyl	[37, 189, 190]
25B-NBF		H	2,5-dimethoxy-4-bromo	N-(2-fluorobenzyl)-1-(2,5-dimethoxy-4-bromophenyl)-2-aminoethane	2-fluorophenyl	[188, 189]
25C-NBF		H	2,5-dimethoxy-4-chloro	N-(2-fluorobenzyl)-1-(2,5-dimethoxy-4-chlorophenyl)-2-aminoethane	2-fluorophenyl	[37, 38, 187–191]
25I-NBF		H	2,5-dimethoxy-4-iodo	N-(2-fluorobenzyl)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminoethane	2-fluorophenyl	[37, 38, 187–191]
25B-NBOH		H	2,5-dimethoxy-4-bromo	N-(2-hydroxybenzyl)-1-(2,5-dimethoxy-4-bromophenyl)-2-aminoethane	2-hydroxyphenyl	[190, 191]
25C-NBOH		H	2,5-dimethoxy-4-chloro	N-(2-hydroxybenzyl)-1-(2,5-dimethoxy-4-chlorophenyl)-2-aminoethane	2-hydroxyphenyl	[37, 190]
25CN-NBOH		H	2,5-dimethoxy-4-cyano	N-(2-hydroxybenzyl)-1-(2,5-dimethoxy-4-cyanophenyl)-2-aminoethane	2-hydroxyphenyl	[188, 190]
25E-NBOH		H	2,5-dimethoxy-4-ethyl	N-(2-hydroxybenzyl)-1-(2,5-dimethoxy-4-ethylphenyl)-2-aminoethane	2-hydroxyphenyl	[187, 188, 190]
25I-NBOH		H	2,5-dimethoxy-4-iodo	N-(2-hydroxybenzyl)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminoethane	2-hydroxyphenyl	[37, 38, 187–191]
25D-NBOH		H	2,5-dimethoxy-4-methyl	N-(2-hydroxybenzyl)-1-(2,5-dimethoxy-4-methylphenyl)-2-aminoethane	2-hydroxyphenyl	[38, 188, 190]
25P-NBOH		H	2,5-dimethoxy-4-propyl	N-(2-hydroxybenzyl)-1-(2,5-dimethoxy-4-propylphenyl)-2-aminoethane	2-hydroxyphenyl	[37, 38, 188]
25T7-NBOH		H	2,5-dimethoxy-4-(propylthio)	N-(2-hydroxybenzyl)-1-[2,5-dimethoxy-4-(propylthio)phenyl]-2-aminoethane	2-hydroxyphenyl	[189, 191]
25C-NBOiPr		H	2,5-dimethoxy-4-chloro	N-(2-isopropoxybenzyl)-1-(2,5-dimethoxy-4-chlorophenyl)-2-aminoethane	2-isopropoxyphenyl	[187, 188, 190]
25G-NBOMe		H	2,5-dimethoxy-3,4-dimethyl	N-(2-methoxybenzyl)-1-(2,5-dimethoxy-3,4-dimethylphenyl)-2-aminoethane	2-methoxyphenyl	[189, 190]
25B-NBOMe		H	2,5-dimethoxy-4-bromo	N-(2-methoxybenzyl)-1-(2,5-dimethoxy-4-bromophenyl)-2-aminoethane	2-methoxyphenyl	[37, 38, 187–191]
DOB-NBOMe		methyl	2,5-dimethoxy-4-bromo	N-(2-methoxybenzyl)-1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane	2-methoxyphenyl	[37, 38, 187–191]
25C-NBOMe		H	2,5-dimethoxy-4-chloro	N-(2-methoxybenzyl)-1-(2,5-dimethoxy-4-chlorophenyl)-2-aminoethane	2-methoxyphenyl	[188–190]
25CN-NBOMe		H	2,5-dimethoxy-4-cyano	N-(2-methoxybenzyl)-1-(2,5-dimethoxy-4-cyanophenyl)-2-aminoethane	2-methoxyphenyl	[37, 188, 189]
25E-NBOMe		H	2,5-dimethoxy-4-ethyl	N-(2-methoxybenzyl)-1-(2,5-dimethoxy-4-ethylphenyl)-2-aminoethane	2-methoxyphenyl	[38, 188, 191]
25F-NBOMe		H	2,5-dimethoxy-4-fluoro	N-(2-methoxybenzyl)-1-(2,5-dimethoxy-4-fluorophenyl)-2-aminoethane	2-methoxyphenyl	[189–191]
25I-NBOMe		H	2,5-dimethoxy-4-iodo	N-(2-methoxybenzyl)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminoethane	2-methoxyphenyl	[188–190]
DOI-NBOMe		methyl	2,5-dimethoxy-4-iodo	N-(2-methoxybenzyl)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane	2-methoxyphenyl	[37, 38, 187, 188, 190, 191]
25iP-NBOMe		H	2,5-dimethoxy-4-isopropyl	N-(2-methoxybenzyl)-1-(2,5-dimethoxy-4-isopropylphenyl)-2-aminoethane	2-methoxyphenyl	[37, 38, 187, 188, 190]
25D-NBOMe		H	2,5-dimethoxy-4-methyl	N-(2-methoxybenzyl)-1-(2,5-dimethoxy-4-methylphenyl)-2-aminoethane	2-methoxyphenyl	[187–191]
25N-NBOMe		H	2,5-dimethoxy-4-nitro	N-(2-methoxybenzyl)-1-(2,5-dimethoxy-4-nitrophenyl)-2-aminoethane	2-methoxyphenyl	[37, 188–190]
25P-NBOMe		H	2,5-dimethoxy-4-propyl	N-(2-methoxybenzyl)-1-(2,5-dimethoxy-4-propylphenyl)-2-aminoethane	2-methoxyphenyl	[187–190]
25H-NBOMe		H	2,5-dimethoxy	N-(2-methoxybenzyl)-1-(2,5-dimethoxyphenyl)-2-aminoethane	2-methoxyphenyl	[187–190]
NBOMe-mescaline		H	3,4,5-trimethoxy	N-(2-methoxybenzyl)-1-(3,4,5-trimethoxyphenyl)-2-aminoethane	2-methoxyphenyl	[187–190]
MDPEA-NBOMe		H	3,4-methylenedioxy	N-(2-methoxybenzyl)-1-(3,4-methylenedioxyphenyl)-2-aminoethane	2-methoxyphenyl	[187, 189, 191]
NBOMe-escaline		H	3,5-dimethoxy-4-ethoxy	N-(2-methoxybenzyl)-1-(3,5-dimethoxy-4-ethoxyphenyl)-2-aminoethane	2-methoxyphenyl	[188–190]
4-EA-NBOMe		methyl	4-ethyl	N-(2-methoxybenzyl)-1-(4-ethylphenyl)-2-aminopropane	2-methoxyphenyl	[37, 38, 187–191]
5-APB-NBOMe		methyl	benzofuraN-5-yl instead of phenyl	N-(2-methoxybenzyl)-1-(benzofuraN-5-yl)-2-aminopropane	2-methoxyphenyl	[37, 38, 187–191]
25T2-NBOMe		H	2,5-dimethoxy-4-(ethylthio)	N-(2-methoxybenzyl)-1-[2,5-dimethoxy-4-(ethylthio)phenyl]-2-aminoethane	2-methoxyphenyl	[37, 187, 188, 190]
25T4-NBOMe		H	2,5-dimethoxy-4-(isopropylthio)	N-(2-methoxybenzyl)-1-[2,5-dimethoxy-4-(isopropylthio)phenyl]-2-aminoethane	2-methoxyphenyl	[187, 190, 191]
25T-NBOMe		H	2,5-dimethoxy-4-(methylthio)	N-(2-methoxybenzyl)-1-[2,5-dimethoxy-4-(methylthio)phenyl]-2-aminoethane	2-methoxyphenyl	[37, 38, 191]
25T7-NBOMe		H	2,5-dimethoxy-4-(propylthio)	N-(2-methoxybenzyl)-1-[2,5-dimethoxy-4-(propylthio)phenyl]-2-aminoethane	2-methoxyphenyl	[187, 188, 190, 191]
25TFM-NBOMe		H	2,5-dimethoxy-4-(trifluoromethyl)	N-(2-methoxybenzyl)-1-[2,5-dimethoxy-4-(trifluoromethyl)phenyl]-2-aminoethane	2-methoxyphenyl	[187, 188, 191]
C30-NBOMe		H	2,5-dimethoxy-4-chloro	N-(3,4,5-trimethoxybenzyl)-1-(2,5-dimethoxy-4-chlorophenyl)-2-aminoethane	3,4,5-trimethoxyphenyl	[190, 191]
25I-NB34MD		H	2,5-dimethoxy-4-iodo	N-(3,4-methylenedioxybenzyl)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminoethane	3,4-methylenedioxyphenyl	[187, 188, 191]
25C-NB3OMe		H	2,5-dimethoxy-4-chloro	N-(3-methoxybenzyl)-1-(2,5-dimethoxy-4-chlorophenyl)-2-aminoethane	3-methoxyphenyl	[37, 38, 187–191]
25I-NB3OMe		H	2,5-dimethoxy-4-iodo	N-(3-methoxybenzyl)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminoethane	3-methoxyphenyl	[188, 189, 191]
25C-NB4OMe		H	2,5-dimethoxy-4-chloro	N-(4-methoxybenzyl)-1-(2,5-dimethoxy-4-chlorophenyl)-2-aminoethane	4-methoxyphenyl	[188, 189, 191]
25I-NB4OMe		H	2,5-dimethoxy-4-iodo	N-(4-methoxybenzyl)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminoethane	4-methoxyphenyl	[187, 189–191]
25I-N2Nap1OH		H	2,5-dimethoxy-4-iodo	N-[(1-hydroxynaphthaleN-2-yl)methyl]-1-(2,5-dimethoxy-4-iodophenyl)-2-aminoethane	1-hydroxynaphthaleN-2-yl	[37, 187–191]
25B-NMe7DHBF		H	2,5-dimethoxy-4-bromo	N-[(2,3-dihydrobenzofuraN-7-yl)methyl]-1-(2,5-dimethoxy-4-bromophenyl)-2-aminoethane	2,3-dihydrobenzofuraN-7-yl	[37, 187–191]
25I-NMe7DHBF		H	2,5-dimethoxy-4-iodo	N-[(2,3-dihydrobenzofuraN-7-yl)methyl]-1-(2,5-dimethoxy-4-iodophenyl)-2-aminoethane	2,3-dihydrobenzofuraN-7-yl	[188–190]
FECIMBI-36		H	2,5-dimethoxy-4-bromo	N-[(2-fluoroethoxy)benzyl]-1-(2,5-dimethoxy-4-bromophenyl)-2-aminoethane	2-(2-fluoroethoxy)phenyl	[189–191]
25I-N3MT2M		H	2,5-dimethoxy-4-iodo	N-[(3-methoxythiopheN-2-yl)methyl]-1-(2,5-dimethoxy-4-iodophenyl)-2-aminoethane	3-methoxythiopheN-2-yl	[37, 38, 190]
25I-N4MT3M		H	2,5-dimethoxy-4-iodo	N-[(4-methoxythiopheN-3-yl)methyl]-1-(2,5-dimethoxy-4-iodophenyl)-2-aminoethane	4-methoxythiopheN-3-yl	[37, 38, 190]
25B-NMe7Bim		H	2,5-dimethoxy-4-bromo	N-[(benzimidazol-7-yl)methyl]-1-(2,5-dimethoxy-4-bromophenyl)-2-aminoethane	Benzimidazol-7-yl	[187–191]
25B-NMe7BF		H	2,5-dimethoxy-4-bromo	N-[(benzofuraN-7-yl)methyl]-1-(2,5-dimethoxy-4-bromophenyl)-2-aminoethane	benzofuraN-7-yl	[187, 190, 191]
25B-NMe7BT		H	2,5-dimethoxy-4-bromo	N-[(benzothiopheN-7-yl)methyl]-1-(2,5-dimethoxy-4-bromophenyl)-2-aminoethane	benzothiopheN-7-yl	[37, 38, 187–191]
25B-NMe7Box		H	2,5-dimethoxy-4-bromo	N-[(benzoxazol-7-yl)methyl]-1-(2,5-dimethoxy-4-bromophenyl)-2-aminoethane	Benzoxazol-7-yl	[187–190]
25I-NMeFur		H	2,5-dimethoxy-4-iodo	N-[(furaN-2-yl)methyl]-1-(2,5-dimethoxy-4-iodophenyl)-2-aminoethane	furaN-2-yl	[187–190]
25B-NMe7Indz		H	2,5-dimethoxy-4-bromo	N-[(indazol-7-yl)methyl]-1-(2,5-dimethoxy-4-bromophenyl)-2-aminoethane	indazol-7-yl	[187, 188, 191]
25B-NMe7Ind		H	2,5-dimethoxy-4-bromo	N-[(indol-7-yl)methyl]-1-(2,5-dimethoxy-4-bromophenyl)-2-aminoethane	indol-7-yl	[37, 38, 187–191]
25B-NMePyr		H	2,5-dimethoxy-4-bromo	N-[(pyridiN-2-yl)methyl]-1-(2,5-dimethoxy-4-bromophenyl)-2-aminoethane	pyridiN-2-yl	[37, 187, 190]
25I-NMeTHF		H	2,5-dimethoxy-4-iodo	N-[(tetrahydrofuraN-2-yl)methyl]-1-(2,5-dimethoxy-4-iodophenyl)-2-aminoethane	tetrahydrofuraN-2-yl	[37, 187, 190]
25I-NMeTh		H	2,5-dimethoxy-4-iodo	N-[(thiopheN-2-yl)methyl]-1-(2,5-dimethoxy-4-iodophenyl)-2-aminoethane	thiopheN-2-yl	[187, 189, 191]
25I-NBAm		H	2,5-dimethoxy-4-iodo	N-[2-(carbamoyl)benzyl]-1-(2,5-dimethoxy-4-iodophenyl)-2-aminoethane	2-(carbamoyl)phenyl	[38, 189–191]
25I-NBMeOH		H	2,5-dimethoxy-4-iodo	N-[2-(hydroxymethyl)benzyl]-1-(2,5-dimethoxy-4-iodophenyl)-2-aminoethane	2-(hydroxymethyl)phenyl	[188, 189, 191]
25I-NBTFM		H	2,5-dimethoxy-4-iodo	N-[2-(trifluoromethyl)benzyl]-1-(2,5-dimethoxy-4-iodophenyl)-2-aminoethane	2-(trifluoromethyl)phenyl	[187–190]
25B-NB		H	2,5-dimethoxy-4-bromo	N-benzyl-1-(2,5-dimethoxy-4-bromophenyl)-2-aminoethane	Phenyl	[187, 188, 190]
25C-NB		H	2,5-dimethoxy-4-chloro	N-benzyl-1-(2,5-dimethoxy-4-chlorophenyl)-2-aminoethane	Phenyl	[37, 38, 187–191]
25I-NB		H	2,5-dimethoxy-4-iodo	N-benzyl-1-(2,5-dimethoxy-4-iodophenyl)-2-aminoethane	Phenyl	[187–190]
MDBZ		methyl	3,4-methylenedioxy	N-benzyl-1-(3,4-methylenedioxyphenyl)-2-aminopropane	Phenyl	[37, 38, 187, 190, 191]