Natural Anthraquinones as Promising MAPK3 Inhibitors for Complementary Cancer Therapy

Figure 1

The ΔG_binding values indicate the Gibbs free binding energy in kcal/mol units between anthraquinones, the MAPK3 positive control inhibitor, and the receptor’s active site. Ligand names are shown on the X-axis, and their corresponding Gibbs free binding energy is presented on the Y-axis. The green diamond represents the positive control inhibitor, the red spots depict the most potent MAPK3 inhibitors in this study, and the orange spots show compounds with higher binding affinity to MAPK3 than the reference drug. MAPK3, mitogen-activated protein kinase-3.