Development of Modified-Release Diclofenac Sodium Capsules Using Blends of Pectin-Clay Multiparticulate Hybrid Systems as Release Retardants

Table 1

Working formula for diclofenac pectin-clay capsules.

Ingredients (mg)	F1	F2	F3	A1	A2	A3	C1
Diclofenac sodium	50	50	50	50	50	50	50
CPH pectin	50	50	50	50	50	50	50
Bentonite	10	25	50	0	0	0	0
Talc	0	0	0	10	25	50	0
Dicalcium phosphate	90	75	50	90	75	50	100
Distilled water	q.s	q.s	q.s	q.s	q.s	q.s	q.s