Development of Modified-Release Diclofenac Sodium Capsules Using Blends of Pectin-Clay Multiparticulate Hybrid Systems as Release Retardants

Table 5

Uniformity of the weight and diclofenac content of pectin-clay diclofenac multiparticulate matrix capsules.

Formulation codes	% Diclofenac content	Total net weight (mg)	Average net weight (mg)	No. of capsules deviating by ± 7.5%	No. of capsules deviating by ± 15%	Inferences
A1	103.960 ± 0.04	6024.260	301.213 ± 0.41	Nil	Nil	Pass
A2	104.640 ± 0.06	5983.400	299.170 ± 0.09	Nil	Nil	Pass
A3	105.230 ± 0.05	6000.110	300.011 ± 0.01	Nil	Nil	Pass
F1	97.680 ± 0.03	6250.010	312.501 ± 0.13	Nil	Nil	Pass
F2	97.480 ± 0.03	6264.220	313.211 ± 0.01	Nil	Nil	Pass
F3	97.370 ± 0.03	6217.140	310.201 ± 0.08	Nil	Nil	Pass
C1	97.360 ± 0.03	6244.040	312.201 ± 0.03	Nil	Nil	Pass

Values presented as the mean ± SEM (n = 3, % diclofenac content; n = 20, uniformity of weight).