Development of Modified-Release Diclofenac Sodium Capsules Using Blends of Pectin-Clay Multiparticulate Hybrid Systems as Release Retardants

Table 6

Kinetics and mechanism of diclofenac release from pectin-clay multiparticulate composite capsules.

Formulation coded	Zero order	First order	Higuchi	Hixson–Crowell	Korsmeyer–Peppas
	R^2	R^2	R^2	R^2	R^2	N
A1	0.9632	0.9211	0.9408	0.9486	0.9820	0.6171
A2	0.9370	0.8879	0.9062	0.9183	0.9683	1.3550
A3	0.9085	0.8783	0.8707	0.9010	0.9327	1.9648
F1	0.8738	0.8427	0.8166	0.8231	0.8096	1.4352
F2	0.8417	0.7987	0.7980	0.7887	0.7986	1.5185
F3	0.8113	0.7806	0.7941	0.7757	0.8191	1.5463
C1	0.9977	0.8776	0.9919	0.9551	0.9989	1.1273