Molecular Design and In-Silico Analysis of Trisubstituted Benzimidazole Derivatives as Ftsz Inhibitor

Table 5

Toxicity score and logPapp of top 7 compounds.

Compound	Toxicity score	Toxicity class	LD50 (mg/kg)	LogPapp
A6	0.938	IV	320	−4.629
A10	0.942	IV	320	−5.358
A11	0.933	IV	320	−5.358
A15	0.909	IV	320	−5.358
A16	0.938	V	2000	−4.629
A18	0.936	V	2000	−5.358
A19	0.933	V	2000	−5.358

Note. “Toxicity classes are defined according to the globally harmonized system of classification of labelling of chemicals (GHS). LD50 values are given in [mg/kg]: class I: fatal if swallowed (LD50 ≤ 5), class II: fatal if swallowed (5 < LD50 ≤ 50), class III: toxic if swallowed (50 < LD50 ≤ 300), class IV: harmful if swallowed (300 < LD50 ≤ 2000), class V: may be harmful if swallowed (2000LD50 ≤ 5000), class VI: nontoxic (LD50 > 5000) [52].”