Research Article
Design and In Silico and In Vitro Evaluations of a Novel Nicotinamide Derivative as a VEGFR-2 Inhibitor
Table 1
PLIP analysis of the targeted nicotinamide derivative in the VEGFR-2 protein for the 4 cluster representatives.
| | Cluster no. | H-B | AA | H-I | AA |
| | C1 | 3 | Cys917-Ile1023-Asp1044 | 10 | Leu838 (2)-Ile886-Val897 (2)-Val914-Leu1017-Ile1023-Leu1033-Asp1044 | | C2 | 3 | Cys917-Ile1023-Asp1044 | 7 | Leu838-Val897 (2)-Val914-Ile1023-Leu1033-Asp1044 | | C3 | 6 | Glu915-Cys917-Ile1023 (2)-Asp1044 (2) | 7 | Leu838-Val897 (2)-Val914-Ile1023-Leu1033-Asp1044 | | C4 | 4 | Cys917-Ile1023 (2)-Asp1044 | 10 | Leu838-Ala864-Ile886-Ile890-Val897 (2)-Leu1017-Ile1023-Leu1033-Asp1044 |
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Bold represents the most common amino acids.
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