Novel Xanthene-1,8-dione Derivatives Containing the Benzylic Ether Tail as Potent Cytotoxic Agents: Design, Synthesis, In Vitro, and In Silico Studies

<div>Structure of some covalent (I–III) and noncovalent (IV and V) DNA binding agents. Overlay of Daunomycin (red) and synthesized general xanthene-1,8-dione derivative (blue) showed that the tricyclic system matched with the A-B-C ring system in Daunomycin.</div>

Journal of Chemistry

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Figure 1: Novel Xanthene-1,8-dione Derivatives Containing the Benzylic Ether Tail as Potent Cytotoxic Agents: Design, Synthesis, In Vitro, and In Silico Studies 

Figure 1 | Novel Xanthene-1,8-dione Derivatives Containing the Benzylic Ether Tail as Potent Cytotoxic Agents: Design, Synthesis, In Vitro, and In Silico Studies 