Novel Xanthene-1,8-dione Derivatives Containing the Benzylic Ether Tail as Potent Cytotoxic Agents: Design, Synthesis, In Vitro, and In Silico Studies

<div>Orientation of Daunomycin and <b>4a</b> in complex with D(CPGPTPAPCPG) DNA strand. Ligands are shown by orange sticks. The proper substitutions at meta position of phenoxy or ortho position of benzyl can occupy the same binding region of aminoglycoside.</div>

Journal of Chemistry

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Figure 3: Novel Xanthene-1,8-dione Derivatives Containing the Benzylic Ether Tail as Potent Cytotoxic Agents: Design, Synthesis, In Vitro, and In Silico Studies 

Figure 3 | Novel Xanthene-1,8-dione Derivatives Containing the Benzylic Ether Tail as Potent Cytotoxic Agents: Design, Synthesis, In Vitro, and In Silico Studies 