Novel Xanthene-1,8-dione Derivatives Containing the Benzylic Ether Tail as Potent Cytotoxic Agents: Design, Synthesis, In Vitro, and In Silico Studies

Table 1

Xanthene-1,8-dione products derived from 4-hydroxy benzaldehyde (4a–h) or vanillin (4i–q).

Entry	Product
1	4a	H	H	H	H
2	4b	H	H	H	Br
3	4c	H	H	Cl	H
4	4d	H	H	H	F
5	4e	H	F	H	H
6	4f	H	H	F	H
7	4g	H	H	H	CH3
8	4h	H	H	H	Cl
9	4i	OCH3	H	H	H
10	4j	OCH3	H	H	Br
11	4k	OCH3	H	Cl	H
12	4l	OCH3	H	H	F
13	4m	OCH3	F	H	H
14	4n	OCH3	H	F	H
15	4o	OCH3	H	H	CH3
16	4p	OCH3	H	H	Cl
17	4q	H	H	H	CN