Development of Thiazolidinone-Based Pyrazine Derivatives: Synthesis, Molecular Docking Simulation, and Bioevaluation for Anti-Alzheimer and Antibacterial Activities

<div>Synthetic route for the synthesis of pyrazine-based thiazolidinone scaffolds (<b>1–12</b>): (a) different substituted phenylisothiocyanates, EtOH, Et<sub>3</sub>N, and reflux 4 hrs; (b) chloroacetic acid, acetic acid, sodium acetate, and reflux 5 hrs; and (c) 5-chloropyrazin-2-amine, acetic acid, ethanol, and reflux 3 hrs.</div>

Journal of Chemistry

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Scheme 1

Scheme 1: Development of Thiazolidinone-Based Pyrazine Derivatives: Synthesis, Molecular Docking Simulation, and Bioevaluation for Anti-Alzheimer and Antibacterial Activities 

Scheme 1 | Development of Thiazolidinone-Based Pyrazine Derivatives: Synthesis, Molecular Docking Simulation, and Bioevaluation for Anti-Alzheimer and Antibacterial Activities 