Development of Thiazolidinone-Based Pyrazine Derivatives: Synthesis, Molecular Docking Simulation, and Bioevaluation for Anti-Alzheimer and Antibacterial Activities

Table 1

The various substitution patterns of the aromatic ring in the compounds (1–12) along with acetylcholinesterase inhibitory profile.

S/No.	R	AChE inhibition IC50 ± SEM (µM)
1		4.10 ± 0.20
2		2.20 ± 0.20
3		8.10 ± 0.10
4		2.30 ± 0.20
5		5.80 ± 0.30
6		6.30 ± 0.20
7		19.10 ± 0.20
8		5.20 ± 0.10
9		5.20 ± 0.40
10		8.30 ± 0.40
11		8.10 ± 0.70
12		20.30 ± 0.30
Standard donepezil drug		10.10 ± 0.10 µM