Journal of Drug Delivery / 2012 / Article / Fig 2

Review Article

Lipoplatin Formulation Review Article

Figure 2

Penetration of lipoplatin nanoparticles through the cell membrane of tumor cells. lipoplatin nanoparticles once inside the tumor cell mass can fuse with the cell membrane because of the presence of the fusogenic lipid DPPG in their lipid bilayer; an alternative mechanism proposed is that lipoplatin is taken by endocytosis by tumor cells as shown from lipoplatin containing fluorescent lipids and imaging of the tumor cells in culture thus treated with fluorescent microscopy (see Figure 3). These processes occurring at the cell membrane level are promoted by the lipid shell of the nanoparticles (disguised as nutrients) [20].