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International Journal of Experimental Diabetes Research
Volume 1 (2000), Issue 1, Pages 31-38

PROLACTIN-Deficiency in Adult Offspring of Diabetic Mothers

Department Obstetrics and Gynecology, U.Z. Gasthuisberg, K.U. Leuven. Herestraat 49, Leuven B-3001, Belgium

Received 4 June 1999; Accepted 23 August 1999

Copyright © 2000 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Maternal diabetes induces fetal alterations, resulting in lasting consequences for the glucose tolerance of the offspring over several generations. In our experimental rat model, circulating prolactin, oestradiol, progesterone and corticosterone levels, known to influence insulin secretion and action, are determined in plasma of female adult offspring of mildly and severely diabetic mothers. Prolactin and progesterone levels are equally low in both groups as compared to controls, stressing the involvement of the CNS in the transgeneration effect; oestradiol and corticosterone levels are normal. No correlation is found between these hormonal alterations and the known differences in glucose tolerance.