Journal of Diabetes Research

Journal of Diabetes Research / 2001 / Article

Open Access

Volume 2 |Article ID 958042 |

Lisa Månsson, Carina Törn, Mona Landin-Olsson, "Islet Cell Antibodies Represent Autoimmune Response Against Several Antigens", Journal of Diabetes Research, vol. 2, Article ID 958042, 6 pages, 2001.

Islet Cell Antibodies Represent Autoimmune Response Against Several Antigens

Received24 Mar 2000
Accepted02 Jan 2001


To study the antigens involved in the islet cell antibody (ICA) reaction we selected 30 patient serum samples (ten in each group) positive for ICA and one other additional autoantibody, such as glutamic acid decarboxylase antibodies (GADA), thyrosine phosphatase antibodies (IA-2A) or insulin autoantibodies (IAA). The serum samples were incubated with the specific antigen (GAD65, IA-2 or insulin) and the ICA analysis and the corresponding immunoprecipitation assay were performed before and after the absorption.We could then demonstrate that specific autoantibodies against GAD65 and IA-2 could be absorbed with the corresponding antigen, since ten GADA positive and six IA-2A samples turned completely negative. However, the ICA reaction after absorption with GADA, IA-2A and insulin was still present, although at significantly lower levels. The results strongly indicate that the ICA reaction represents simultaneous autoimmunity against several other antigens beside GAD65, IA-2 and insulin.

Copyright © 2001 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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