Journal of Diabetes Research

Journal of Diabetes Research / 2003 / Article

Open Access

Volume 4 |Article ID 395425 |

R. Ananthan, M. Latha, K. M. Ramkumar, L. Pari, C. Baskar, V. Narmatha Bai, "Effect of Gymnema montanum Leaves on Serum and Tissue Lipids in Alloxan Diabetic Rats", Journal of Diabetes Research, vol. 4, Article ID 395425, 7 pages, 2003.

Effect of Gymnema montanum Leaves on Serum and Tissue Lipids in Alloxan Diabetic Rats

Received31 Mar 2003
Accepted17 Jul 2003


The effect of Gymnema montanum leaves on alloxaninduced hyperlipidemia was studied in male Wistar rats. Ethanolic extract of G. montanum leaves was administered orally and different doses of the extract on blood glucose, serum and tissue lipids, hexokinase, glucose-6-phosphatase, thiobarbituric acid–reactive substances (TBARS), hydroperoxides, and glutathione in alloxan-induced diabetic rats were studied. G. montanum leaf extract (GLEt) at doses of 50, 100, 200 mg/kg body weight for 3 weeks suppressed the elevated blood glucose and lipid levels in diabetic rats. GLEt at 200 mg/kg body weight was found to be comparable to glibenclamide, a reference drug. These data indicate that G. montanum represents an effective antihyperglycemic and antihyperlipidemic adjunct for the treatment of diabetes and a potential source of discovery of new orally active agent for future therapy.

Copyright © 2003 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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