Journal of Diabetes Research

Journal of Diabetes Research / 2003 / Article

Open Access

Volume 4 |Article ID 845380 | https://doi.org/10.1080/15438600303731

Shimon Efrat, "β-Cell Expansion for Therapeutic Compensation of Insulin Resistance in Type 2 Diabetes", Journal of Diabetes Research, vol. 4, Article ID 845380, 5 pages, 2003. https://doi.org/10.1080/15438600303731

β-Cell Expansion for Therapeutic Compensation of Insulin Resistance in Type 2 Diabetes

Accepted20 Jan 2003

Abstract

Insulin resistance is the primary cause of type 2 diabetes. However, if compensated by increased insulin production, insulin resistance by itself does not lead to overt disease. Type 2 diabetes develops when this compensation is insufficient, due to defects in β-cell function and in regulation of the β-cell mass. β-Cell transplantation, as well as approaches that replenish or preserve the endogenous β-cell mass, may facilitate the treatment of type 2 diabetes in patients requiring exogenous insulin.

Copyright © 2003 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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