Shimon Efrat, "β-Cell Expansion for Therapeutic Compensation of Insulin Resistance in Type 2 Diabetes", Journal of Diabetes Research, vol. 4, Article ID 845380, 5 pages, 2003. https://doi.org/10.1080/15438600303731
β-Cell Expansion for Therapeutic Compensation of Insulin Resistance in Type 2 Diabetes
Insulin resistance is the primary cause of type 2 diabetes. However, if compensated by increased insulin production, insulin resistance by itself does not lead to overt disease. Type 2 diabetes develops when this compensation is insufficient, due to defects in β-cell function and in regulation of the β-cell mass. β-Cell transplantation, as well as approaches that replenish or preserve the endogenous β-cell mass, may facilitate the treatment of type 2 diabetes in patients requiring exogenous insulin.
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