Role of C-Peptide in the Regulation of Microvascular Blood Flow

<table>Cyclic guanyl monophosphate (cGMP) at baseline and after 60 and 120 minutes of C-peptide (<svg height="9.5375004" id="M42" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 11.8875 9.5375004" width="11.8875" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,9.475)"><path d="M627 0h-562v554h562v-554z" id="x25A0"></path></g>
</svg>) or placebo (<svg height="9.9499998" id="M43" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 11.8875 9.9499998" width="11.8875" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,9.888)"><path d="M639 0h-586v578h586v-578zM581 50v478h-470v-478h470z" id="x25A1"></path></g>
</svg>) (mean ± SEM; <svg height="13.2" id="M44" style="vertical-align:-1.0374pt" version="1.1" viewbox="0 0 78.137497 13.2" width="78.137497" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,11.837)"><path d="M264 363l29 -11q141 -51 141 -167q0 -71 -45.5 -117.5t-124.5 -56.5v-87h-35v85q-93 0 -156 41q-11 32 -28 132l30 8q41 -135 154 -148v242l-36 16q-126 54 -126 153q0 62 42.5 107.5t119.5 54.5v78h35v-76q50 0 89 -13q6 -1 17 -4t17 -4l10 -60.5l11 -64.5l-28 -7
q-16 53 -39 82.5t-77 37.5v-221zM229 376v208q-45 -4 -69 -33t-24 -67q0 -72 93 -108zM264 272v-229q45 6 70 35.5t25 71.5q0 39 -17.5 67t-65.5 50z" id="x24"></path></g><g transform="matrix(.017,-0,0,-.017,12.931,11.837)"><path d="M535 323h-483v50h483v-50zM535 138h-483v50h483v-50z" id="x3D"></path></g><g transform="matrix(.017,-0,0,-.017,27.634,11.837)"><path d="M619 482q0 -69 -40.5 -119t-96 -72.5t-118.5 -26.5h-44l-70 20l-31 -151q-14 -67 0.5 -83t89.5 -22l-5 -28h-287l8 28q65 7 81.5 22t29.5 83l79 398q12 56 0.5 70.5t-78.5 20.5l7 28h255q108 0 164 -43t56 -125zM524 478q0 141 -146 141q-25 0 -47 -8q-16 -6 -20.5 -13.5
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q0 -76 10 -138.5t37 -107.5t69 -45q32 0 55.5 25t35.5 68.5t17.5 91.5t5.5 105t-5.5 105.5t-18 92t-36 68t-56.5 24.5z" id="x30"></path></g><g transform="matrix(.017,-0,0,-.017,69.91,11.837)"><path d="M153 550l-26 -186q79 31 111 31q90 0 141.5 -51t51.5 -119q0 -93 -89 -166q-85 -69 -173 -71q-32 0 -61.5 11.5t-41.5 23.5q-18 17 -17 34q2 16 22 33q14 9 26 -1q61 -50 124 -50q60 0 93 43.5t33 104.5q0 69 -41.5 110t-121.5 41q-53 0 -102 -20l38 305h286l6 -8
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</svg> versus baseline; <svg height="12.9375" id="M45" style="vertical-align:-1.4196pt" version="1.1" viewbox="0 0 78.087502 12.9375" width="78.087502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,11.112)"><path d="M426 201q-1 -104 -99 -213q-63 -69 -138 -92q-41 0 -69 22q-20 15 -20 30q0 14 21 32q11 8 21 3q45 -28 79 -28q28 0 48.5 15.5t21.5 44.5q0 41 -67 104l-99 98q-71 69 -71 152q0 88 79 172q39 43 72.5 65.5t78.5 33.5q40 0 66 -22q12 -12 12 -23q0 -20 -18 -33
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t-10.5 -39.5l-43 -241q37 -13 83 -13q67 0 125.5 45t58.5 129z" id="x1D443"></path></g><g transform="matrix(.017,-0,0,-.017,43.12,11.112)"><path d="M512 -3l-437 233v51l437 233v-58l-378 -200v-2l378 -199v-58z" id="x3C"></path></g><g transform="matrix(.017,-0,0,-.017,57.824,11.112)"><path d="M113 -12q-24 0 -39.5 16t-15.5 42q0 24 16 40.5t40 16.5t40 -16.5t16 -40.5q0 -26 -16 -42t-41 -16z" id="x2E"></path></g><g transform="matrix(.017,-0,0,-.017,61.7,11.112)"><path d="M241 635q53 0 94 -28.5t63.5 -76t33.5 -102.5t11 -116q0 -58 -11 -112.5t-34 -103.5t-63.5 -78.5t-94.5 -29.5t-95 28t-64.5 75t-34.5 102.5t-11 118.5q0 58 11.5 112.5t34.5 103t64.5 78t95.5 29.5zM238 602q-32 0 -55.5 -25t-35.5 -68t-17.5 -91t-5.5 -105
q0 -76 10 -138.5t37 -107.5t69 -45q32 0 55.5 25t35.5 68.5t17.5 91.5t5.5 105t-5.5 105.5t-18 92t-36 68t-56.5 24.5z" id="x30"></path></g><g transform="matrix(.017,-0,0,-.017,69.859,11.112)"><path d="M153 550l-26 -186q79 31 111 31q90 0 141.5 -51t51.5 -119q0 -93 -89 -166q-85 -69 -173 -71q-32 0 -61.5 11.5t-41.5 23.5q-18 17 -17 34q2 16 22 33q14 9 26 -1q61 -50 124 -50q60 0 93 43.5t33 104.5q0 69 -41.5 110t-121.5 41q-53 0 -102 -20l38 305h286l6 -8
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</svg> versus 60 minutes).</table>

Journal of Diabetes Research

Role of C-Peptide in the Regulation of Microvascular Blood Flow

Figure 6