The Effects of C-peptide on Type 1 Diabetic Polyneuropathies and Encephalopathy in the BB/Wor-rat
Figure 3
Longitudinal measurements of thermal
hyperalgesia in type 1 BB/Wor-rats without and with C-peptide replacement from
onset of diabetes compared to duration- and hyperglycemia-matched type 2
BBZDR/Wor-rats and age-matched control rats.
Note more severe hyperalgesia in type 1 as compared to type 2 rats and
with partial but significant prevention in C-peptide treated rats [48, 49].