Recent Insights in Islet Amyloid Polypeptide-Induced Membrane Disruption and Its Role in -Cell Death in Type 2 Diabetes Mellitus

Figure 1

Comparison of the amino acid sequences of human IAPP (hIAPP) and mouse IAPP (mIAPP). Mouse IAPP differs from the human peptide by six residues (in red). The N-terminal region is thought to be responsible for membrane interaction (residues in blue). The amino acid region suggested to be important for fibril formation is represented in the underlined.