AGEs and Glucose Levels Modulate Type I and III Procollagen mRNA Synthesis in Dermal Fibroblasts Cells Culture

<table>The relative expression ratios (<svg height="7.1750002" id="M18" style="vertical-align:-0.1254pt" version="1.1" viewbox="0 0 8.9375 7.1750002" width="8.9375" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,7.175)">
<g transform="translate(72,-66.26)">
<text transform="matrix(1,0,0,-1,-71.95,66.44)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝛼</tspan>
</text>
</g>
</g>
</svg>) for <i>procollagen 1<span class="inline" id=""></span>2</i> and for <i>procollagen 3<span class="inline" id=""></span>1</i> genes after 24 hours
glucose treatment of culture human dermal fibroblasts. <svg height="13.6125" id="M19" style="vertical-align:-2.34499pt" version="1.1" viewbox="0 0 50.037498 13.6125" width="50.037498" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,13.6125)">
<g transform="translate(72,-61.11)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">C</tspan>
<tspan style="font-size: 12.50px; " x="8.3395014" y="0">T</tspan>
<tspan style="font-size: 12.50px; " x="19.442165" y="0">=</tspan>
<tspan style="font-size: 12.50px; " x="31.482553" y="0">𝑓</tspan>
</text>
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</svg> was expressed in arbitrary units. The data are shown as the mean ± SD for two independent experiments run in triplicate each time with significant differences compared
to control (5.5 mM glucose) at 
<sup>*</sup><i>P</i> &lt; .05, 
<sup>**</sup><i>P</i> &lt; .02, 
and <sup>***</sup><i>P</i> &lt; .01.</table>

Journal of Diabetes Research

fig4

Figure 4

Figure 4: AGEs and Glucose Levels Modulate Type I and III Procollagen mRNA Synthesis in Dermal Fibroblasts Cells Culture 