Amyloid Deposition in Transplanted Human Pancreatic Islets: A Conceivable Cause of Their Long-Term Failure
Figure 4
Intra- and extracellular amyloid in an islet
graft implanted under the renal capsule of a nude mouse. (a) In the overview,
it is seen that the amyloid (arrow) is present in the periphery of degranulated
-cells (star). (b) At higher magnification, it is obvious that the
amyloid forms a network, presumably due to presence in the endoplasmic
reticulum. (c) At high magnification, the fibrillar ultrastructure of the
amyloid is evident as well as its specific immunolabelling with antibodies
against IAPP, visualized with 10 nm gold particles.
