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Experimental Diabetes Research
Volume 2008, Article ID 672021, 6 pages
http://dx.doi.org/10.1155/2008/672021
Research Article

Effects of Oral Glucose Load on Endothelial Function and on Insulin and Glucose Fluctuations in Healthy Individuals

1Cardiology Research Clinic Y, Bispebjerg University Hospital, Copenhagen, NV 2400, Denmark
2Cardiology Department P and Laboratory, Gentofte University Hospital, Hellerup 2900, Denmark
3Internal Medicine Clinic I, Bispebjerg University Hospital, Copenhagen, NV 2400, Denmark
4Cardiology department, Rigshospitalet Univeristy Hospital, Copenhagen 2100, Denmark

Received 22 July 2007; Accepted 31 December 2007

Academic Editor: George King

Copyright © 2008 A. Major-Pedersen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Q. Qiao, S. Larsen, K. Borch-Johnsen et al., “Glucose tolerance and cardiovascular mortality. Comparison of fasting and 2-hour diagnostic criteria,” Archives of Internal Medicine, vol. 161, no. 3, pp. 397–405, 2001. View at Publisher · View at Google Scholar
  2. E. Bonora and M. Muggeo, “Postprandial blood glucose as a risk factor for cardiovascular disease in Type II diabetes: the epidemiological evidence,” Diabetologia, vol. 44, no. 12, pp. 2107–2114, 2001. View at Publisher · View at Google Scholar
  3. B. L. Rodriguez, R. D. Abbott, W. Fujimoto et al., “The American diabetes association and world health organization classifications for diabetes: their impact on diabetes prevalence and total and cardiovascular disease mortality in elderly Japanese-American men,” Diabetes Care, vol. 25, no. 6, pp. 951–955, 2002. View at Publisher · View at Google Scholar
  4. M. Tominaga, H. Eguchi, H. Manaka, K. Igarashi, T. Kato, and A. Sekikawa, “Impaired glucose tolerance is a risk factor for cardiovascular disease, but not impaired fasting glucose: the funagata diabetes study,” Diabetes Care, vol. 22, no. 6, pp. 920–924, 1999. View at Publisher · View at Google Scholar
  5. F. de Vegt, J. M. Dekker, H. G. Ruhé et al., “Hyperglycaemia is associated with all-cause and cardiovascular mortality in the Hoorn population: the Hoorn study,” Diabetologia, vol. 42, no. 8, pp. 926–931, 1999. View at Publisher · View at Google Scholar
  6. J. E. Shaw, A. M. Hodge, M. De Courten, P. Chitson, and P. Z. Zimmet, “Isolated post-challenge hyperglycaemia confirmed as a risk factor for mortality,” Diabetologia, vol. 42, no. 9, pp. 1050–1054, 1999. View at Publisher · View at Google Scholar
  7. M. Coutinho, H. C. Gerstein, Y. Wang, and S. Yusuf, “The relationship between glucose and incident cardiovascular events: a metaregression analysis of published data from 20 studies of 95,783 individuals followed for 12.4 years,” Diabetes Care, vol. 22, no. 2, pp. 233–240, 1999. View at Publisher · View at Google Scholar
  8. M. Hanefeld, C. Koehler, F. Schaper, K. Fuecker, E. Henkel, and T. Temelkova-Kurktschiev, “Postprandial plasma glucose is an independent risk factor for increased carotid intima-media thickness in non-diabetic individuals,” Atherosclerosis, vol. 144, no. 1, pp. 229–235, 1999. View at Publisher · View at Google Scholar
  9. B. L. Rodriguez, N. Lau, C. M. Burchfiel et al., “Glucose intolerance and 23-year risk of coronary heart disease and total mortality: the Honolulu heart program,” Diabetes Care, vol. 22, no. 8, pp. 1262–1265, 1999. View at Publisher · View at Google Scholar
  10. T. Temelkova-Kurktschiev, “Significance of postprandial glucose peaks for development of diabetic macroangiopathy,” Therapeutische Umschau, vol. 59, pp. 411–414, 2002. View at Publisher · View at Google Scholar
  11. H. Gaenzer, G. Neumayr, P. Marschang et al., “Effect of insulin therapy on endothelium-dependent dilation in type 2 diabetes mellitus,” The American Journal of Cardiology, vol. 89, no. 4, pp. 431–434, 2002. View at Publisher · View at Google Scholar
  12. A. Ceriello, “Acute hyperglycaemia: a ‘new’ risk factor during myocardial infarction,” European Heart Journal, vol. 26, no. 4, pp. 328–331, 2005. View at Publisher · View at Google Scholar
  13. A. Ceriello, A. Cavarape, L. Martinelli et al., “The post-prandial state in type 2 diabetes and endothelial dysfunction: effects of insulin aspart,” Diabetic Medicine, vol. 21, no. 2, pp. 171–175, 2004. View at Publisher · View at Google Scholar
  14. M. Shimabukuro, N. Higa, I. Chinen, K. Yamakawa, and N. Takasu, “Effects of a single administration of acarbose on postprandial glucose excursion and endothelial dysfunction in type 2 diabetic patients: a randomized crossover study,” Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 3, pp. 837–842, 2006. View at Publisher · View at Google Scholar
  15. M. Shimabukuro, N. Higa, N. Takasu, T. Tagawa, and S. Ueda, “A single dose of nateglinide improves post-challenge glucose metabolism and endothelial dysfunction in type 2 diabetic patients,” Diabetic Medicine, vol. 21, no. 9, pp. 983–986, 2004. View at Publisher · View at Google Scholar
  16. S.-H. Kim, K.-W. Park, Y.-S. Kim et al., “Effects of acute hyperglycemia on endothelium-dependent vasodilation in patients with diabetes mellitus or impaired glucose metabolism,” Endothelium, vol. 10, no. 2, pp. 65–70, 2003. View at Publisher · View at Google Scholar
  17. T. C. Wascher, I. Schmoelzer, A. Wiegratz et al., “Reduction of postchallenge hyperglycaemia prevents acute endothelial dysfunction in subjects with impaired glucose tolerance,” European Journal of Clinical Investigation, vol. 35, no. 9, pp. 551–557, 2005. View at Publisher · View at Google Scholar
  18. D. Giugliano, R. Marfella, L. Coppola et al., “Vascular effects of acute hyperglycemia in humans are reversed by L-arginine: evidence for reduced availability of nitric oxide during hyperglycemia,” Circulation, vol. 95, no. 7, pp. 1783–1790, 1997. View at Google Scholar
  19. L. M. Title, P. M. Cummings, K. Giddens, and B. A. Nassar, “Oral glucose loading acutely attenuates endothelium-dependent vasodilation in healthy adults without diabetes: an effect prevented by vitamins C and E,” Journal of the American College of Cardiology, vol. 36, no. 7, pp. 2185–2191, 2000. View at Publisher · View at Google Scholar
  20. S. B. Williams, A. B. Goldfine, F. K. Timimi et al., “Acute hyperglycemia attenuates endothelium-dependent vasodilation in humans in vivo,” Circulation, vol. 97, no. 17, pp. 1695–1701, 1998. View at Google Scholar
  21. H. Kawano, T. Motoyama, O. Hirashima et al., “Hyperglycemia rapidly suppresses flow-mediated endothelium-dependent vasodilation of brachial artery,” Journal of the American College of Cardiology, vol. 34, no. 1, pp. 146–154, 1999. View at Publisher · View at Google Scholar
  22. J. A. Beckman, M. A. Creager, and P. Libby, “Diabetes and atherosclerosis epidemiology, pathophysiology, and management,” Journal of the American Medical Association, vol. 287, no. 19, pp. 2570–2581, 2002. View at Publisher · View at Google Scholar
  23. J. A. Beckman, A. B. Goldfine, M. B. Gordon, L. A. Garrett, and M. A. Creager, “Inhibition of protein kinase Cβ prevents impaired endothelium-dependent vasodilation caused by hyperglycemia in humans,” Clinical Research, vol. 90, pp. 107–111, 2002. View at Publisher · View at Google Scholar
  24. C. M. Akbari, R. Saouaf, D. F. Barnhill, P. A. Newman, F. W. LoGerfo, and A. Veves, “Endothelium-dependent vasodilatation is impaired in both microcirculation and macrocirculation during acute hyperglycemia,” Journal of Vascular Surgery, vol. 28, no. 4, pp. 687–694, 1998. View at Publisher · View at Google Scholar
  25. A. Ceriello, C. Taboga, L. Tonutti et al., “Evidence for an independent and cumulative effect of postprandial hypertriglyceridemia and hyperglycemia on endothelial dysfunction and oxidative stress generation: effects of short- and long-term simvastatin treatment,” Circulation, vol. 106, no. 10, pp. 1211–1218, 2002. View at Publisher · View at Google Scholar
  26. N. Ihlemann, C. Rask-Madsen, A. Perner et al., “Tetrahydrobiopterin restores endothelial dysfunction induced by an oral glucose challenge in healthy subjects,” American Journal of Physiology—Heart and Circulatory Physiology, vol. 285, no. 2, pp. H875–H882, 2003. View at Publisher · View at Google Scholar
  27. A. J. H. M. Houben, N. C. Schaper, C. H. A. de Haan et al., “Local 24-h hyperglycemia does not affect endothelium-dependent or—independent vasoreactivity in humans,” American Journal of Physiology—Heart and Circulatory Physiology, vol. 270, no. 6, pp. H2014–H2020, 1996. View at Google Scholar
  28. N. Charkoudian, A. Vella, A. S. Reed et al., “Cutaneous vascular function during acute hyperglycemia in healthy young adults,” Journal of Applied Physiology, vol. 93, no. 4, pp. 1243–1250, 2002. View at Publisher · View at Google Scholar
  29. W. Bagg, G. A. Whalley, A. Sathu, G. Gamble, N. Sharpe, and G. D. Braatvedt, “The effect of acute hyperglycaemia on brachial artery flow mediated dilatation in normal volunteers,” Australian and New Zealand Journal of Medicine, vol. 30, no. 3, pp. 344–350, 2000. View at Google Scholar
  30. A. S. Reed, N. Charkoudian, A. Vella, P. Shah, R. A. Rizza, and M. J. Joyner, “Forearm vascular control during acute hyperglycemia in healthy humans,” American Journal of Physiology—Endocrinology and Metabolism, vol. 286, no. 3, pp. E472–E480, 2004. View at Publisher · View at Google Scholar
  31. A. Siafarikas, K. Watts, P. Beye, T. W. Jones, E. A. Davis, and D. J. Green, “Lack of effect of oral glucose loading on conduit vessel endothelial function in healthy subjects,” Clinical Science, vol. 107, no. 2, pp. 191–196, 2004. View at Publisher · View at Google Scholar
  32. R. P. Hoffman, M. Hausberg, C. A. Sinkey, and E. A. Anderson, “Hyperglycemia without hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans,” Journal of Diabetes and Its Complications, vol. 13, no. 1, pp. 17–22, 1999. View at Publisher · View at Google Scholar
  33. S. van Veen, M. Frölich, and P. C. Chang, “Acute hyperglycaemia in the forearm induces vasodilation that is not modified by hyperinsulinaemia,” Journal of Human Hypertension, vol. 13, no. 4, pp. 263–268, 1999. View at Publisher · View at Google Scholar
  34. D. Taubert, A. Rosenkranz, R. Berkels, R. Roesen, and E. Schömig, “Acute effects of glucose and insulin on vascular endothelium,” Diabetologia, vol. 47, no. 12, pp. 2059–2071, 2004. View at Publisher · View at Google Scholar
  35. M. J. Cipolla, J. M. Porter, and G. Osol, “High glucose concentrations dilate cerebral arteries and diminish myogenic tone through an endothelial mechanism,” Stroke, vol. 28, no. 2, pp. 405–410, 1997, discussion 410-411. View at Google Scholar
  36. T. M. S. Wolever, J.-L. Chiasson, A. Csima et al., “Variation of postprandial plasma glucose, palatability, and symptoms associated with a standardized mixed test meal versus 75 g oral glucose,” Diabetes Care, vol. 21, no. 3, pp. 336–340, 1998. View at Publisher · View at Google Scholar
  37. D. S. Celermajer, K. E. Sorensen, V. M. Gooch et al., “Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis,” Lancet, vol. 340, no. 8828, pp. 1111–1115, 1992. View at Publisher · View at Google Scholar
  38. M. C. Corretti, T. J. Anderson, E. J. Benjamin et al., “Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the international brachial artery reactivity task force,” Journal of the American College of Cardiology, vol. 39, no. 2, pp. 257–265, 2002. View at Publisher · View at Google Scholar
  39. V. R. Newey and D. K. Nassiri, “Online artery diameter measurement in ultrasound images using artificial neural networks,” Ultrasound in Medicine and Biology, vol. 28, no. 2, pp. 209–216, 2002. View at Publisher · View at Google Scholar
  40. L. Lind, J. Hall, A. Larsson, M. Annuk, B. Fellström, and H. Lithell, “Evaluation of endothelium-dependent vasodilation in the human peripheral circulation,” Clinical Physiology, vol. 20, no. 6, pp. 440–448, 2000. View at Publisher · View at Google Scholar
  41. K. Esposito, F. Nappo, R. Marfella et al., “Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress,” Circulation, vol. 106, no. 16, pp. 2067–2072, 2002. View at Publisher · View at Google Scholar
  42. H. Elrick, L. Stimmler, C. J. Hlad Jr., and Y. Arai, “Plasma insulin response to oral and intravenous glucose administration,” Journal of Clinical Endocrinology & Metabolism, vol. 24, pp. 1076–1082, 1964. View at Google Scholar
  43. J. H. Fuller, M. J. Shipley, G. Rose, R. J. Jarrett, and H. Keen, “Coronary-heart-disease risk and impaired glucose tolerance. The Whitehall study,” Lancet, vol. 1, no. 8183, pp. 1373–1376, 1980. View at Google Scholar
  44. M. Pyörälä, H. Miettinen, P. Halonen, M. Laakso, and K. Pyörälä, “Insulin resistance syndrome predicts the risk of coronary heart disease and stroke in healthy middle-aged men: the 22-year follow-up results of the Helsinki policemen study,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 20, no. 2, pp. 538–544, 2000. View at Google Scholar
  45. G. N. Thomas, P. Chook, M. Qiao et al., “Deleterious impact of “high normal” glucose levels and other metabolic syndrome components on arterial endothelial function and intima-media thickness in apparently healthy Chinese subjects: the CATHAY study,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 24, no. 4, pp. 739–743, 2004. View at Publisher · View at Google Scholar
  46. C. Rask-Madsen, N. Ihlemann, T. Krarup et al., “Insulin therapy improves insulin-stimulated endothelial function in patients with type 2 diabetes and ischemic heart disease,” Diabetes, vol. 50, pp. 2611–2618, 2001. View at Google Scholar
  47. J. A. Beckman, A. B. Goldfine, M. B. Gordon, and M. A. Creager, “Ascorbate restores endothelium-dependent vasodilation impaired by acute hyperglycemia in humans,” Circulation, vol. 103, no. 12, pp. 1618–1623, 2001. View at Google Scholar
  48. C. Cardillo, C. M. Kilcoyne, S. S. Nambi, R. O. Cannon III, M. J. Quon, and J. A. Panza, “Vasodilator response to systemic but not to local hyperinsulinemia in the human forearm,” Hypertension, vol. 32, no. 4, pp. 740–745, 1998. View at Google Scholar
  49. A. Ceriello, C. Taboga, L. Tonutti et al., “Evidence for an independent and cumulative effect of postprandial hypertriglyceridemia and hyperglycemia on endothelial dysfunction and oxidative stress generation: effects of short- and long-term simvastatin treatment,” Circulation, vol. 106, no. 10, pp. 1211–1218, 2002. View at Publisher · View at Google Scholar
  50. J.-H. Bae, E. Bassenge, K.-B. Kim et al., “Postprandial hypertriglyceridemia impairs endothelial function by enhanced oxidant stress,” Atherosclerosis, vol. 155, no. 2, pp. 517–523, 2001. View at Publisher · View at Google Scholar
  51. M. Hanefeld and T. Temelkova-Kurktschiev, “The postprandial state and the risk of atherosclerosis,” Diabetic Medicine, vol. 14, 3, pp. S6–S11, 1997. View at Publisher · View at Google Scholar
  52. R. A. Anderson, M. L. Evans, G. R. Ellis et al., “The relationships between post-prandial lipaemia, endothelial function and oxidative stress in healthy individuals and patients with type 2 diabetes,” Atherosclerosis, vol. 154, no. 2, pp. 475–483, 2001. View at Publisher · View at Google Scholar