Human Islet Amyloid Polypeptide Transgenic Mice: In Vivo and Ex Vivo Models for the Role of hIAPP in Type 2 Diabetes Mellitus

Figure 1

Plasma insulin and glucose levels immediately before and at different timepoints after an intraperitoneal injection of glucose (1 g/kg body weight) in anaesthetized, nonfasted nontransgenic (NT, dotted line), and hIAPP transgenic mice (solid line) on a high-fat diet for 14 months. Mean values and SEM are shown; 𝑛=5–11 per group of mice; statistically significant changes between hIAPP and NT mice are indicated by ^*(P < .05) and ^**(P < .01).

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