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Experimental Diabetes Research
Volume 2008 (2008), Article ID 704045, 9 pages
Research Article

The Characterization of High-Fat Diet and Multiple Low-Dose Streptozotocin Induced Type 2 Diabetes Rat Model

Department of Pharmacology, School of Basic Medical Sciences, Jilin University, Changchun, Jilin 130021, China

Received 5 June 2008; Revised 14 October 2008; Accepted 19 November 2008

Academic Editor: Timothy Kern

Copyright © 2008 Ming Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. J. Reed, K. Meszaros, L. J. Entes et al., “A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat,” Metabolism, vol. 49, no. 11, pp. 1390–1394, 2000. View at Publisher · View at Google Scholar
  2. K. Srinivasan, B. Viswanad, L. Asrat, C. L. Kaul, and P. Ramarao, “Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening,” Pharmacological Research, vol. 52, no. 4, pp. 313–320, 2005. View at Publisher · View at Google Scholar
  3. F. Franconi, G. Seghieri, S. Canu, E. Straface, I. Campesi, and W. Malorni, “Are the available experimental models of type 2 diabetes appropriate for a gender perspective?” Pharmacological Research, vol. 57, no. 1, pp. 6–18, 2008. View at Publisher · View at Google Scholar
  4. K. Sahin, M. Onderci, M. Tuzcu et al., “Effect of chromium on carbohydrate and lipid metabolism in a rat model of type 2 diabetes mellitus: the fat-fed, streptozotocin-treated rat,” Metabolism, vol. 56, no. 9, pp. 1233–1240, 2007. View at Publisher · View at Google Scholar
  5. S. Zhao, Y. Chu, C. Zhang et al., “Diet-induced central obesity and insulin resistance in rabbits,” Journal of Animal Physiology and Animal Nutrition, vol. 92, no. 1, pp. 105–111, 2008. View at Publisher · View at Google Scholar
  6. S. Tanaka, T. Hayashi, T. Toyoda et al., “High-fat diet impairs the effects of a single bout of endurance exercise on glucose transport and insulin sensitivity in rat skeletal muscle,” Metabolism, vol. 56, no. 12, pp. 1719–1728, 2007. View at Publisher · View at Google Scholar
  7. A. M. Flanagan, J. L. Brown, C. A. Santiago, P. Y. Aad, L. J. Spicer, and M. T. Spicer, “High-fat diets promote insulin resistance through cytokine gene expression in growing female rats,” The Journal of Nutritional Biochemistry, vol. 19, no. 8, pp. 505–513, 2008. View at Publisher · View at Google Scholar
  8. T. Szkudelski, “The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas,” Physiological Research, vol. 50, no. 6, pp. 537–546, 2001. View at Google Scholar
  9. Y. Kannan, M. Tokunaga, M. Moriyama, H. Kinoshita, and Y. Nakamura, “Beneficial effects of troglitazone on neutrophil dysfunction in multiple low-dose streptozotocin-induced diabetic mice,” Clinical and Experimental Immunology, vol. 137, no. 2, pp. 263–271, 2004. View at Publisher · View at Google Scholar
  10. C. F. Howarth, A. Qureshi, A. Shahin, and M. L. Lukic, “Effects of single high-dose and multiple low-dose streptozotocin on contraction and intracellular Ca2+ in ventricular myocytes from diabetes resistant and susceptible rats,” Molecular and Cellular Biochemistry, vol. 269, no. 1, pp. 103–108, 2005. View at Publisher · View at Google Scholar
  11. N. T. E. Friesen, A. S. Büchau, P. Schott-Ohly, A. Lgssiar, and H. Gleichmann, “Generation of hydrogen peroxide and failure of antioxidative responses in pancreatic islets of male C57BL/6 mice are associated with diabetes induced by multiple low doses of streptozotocin,” Diabetologia, vol. 47, no. 4, pp. 676–685, 2004. View at Publisher · View at Google Scholar
  12. R. Sotnikova, S. Skalska, L. Okruhlicova et al., “Changes in the function and ultrastructure of vessels in the rat model of multiple low dose streptozotocin-induced diabetes,” General Physiology and Biophysics, vol. 25, no. 3, pp. 289–302, 2006. View at Google Scholar
  13. E. Kim, S. Sohn, M. Lee, J. Jung, R. D. Kineman, and S. Park, “Differential responses of the growth hormone axis in two rat models of streptozotocin-induced insulinopenic diabetes,” Journal of Endocrinology, vol. 188, no. 2, pp. 263–270, 2006. View at Publisher · View at Google Scholar
  14. J. R. Wright Jr. and P. E. Lacy, “Synergistic effects of adjuvants, endotoxin, and fasting on induction of diabetes with multiple low doses of streptozocin in rats,” Diabetes, vol. 37, no. 1, pp. 112–118, 1988. View at Google Scholar
  15. Q. M. Chen and M. Z. Xie, “Studies on the hypoglycemic effect of Coptis chinensis and berberine,” Yao Xue Xue Bao, vol. 21, no. 6, pp. 401–406, 1986 (Chinese). View at Google Scholar
  16. Y. X. Ni, “Therapeutic effect of berberine on 60 patients with type II diabetes mellitus and experimental research,” Zhong Xi Yi Jie He Za Zhi, vol. 8, no. 12, pp. 711–713, 1988 (Chinese). View at Google Scholar
  17. Y. H. Yuan, “Clinical trail of berberine as pharmaceutical agent of type 2 diabetes,” Modern Journal of Integrated Traditional Chinese and Western Medicine, vol. 8, p. 1777, 1999 (Chinese). View at Google Scholar
  18. K. Z. Lee, “Clinical trails of berberine chloride as pharmaceutical agent of type II diabetes,” Hubei Journal of Traditional Chinese Medicine, vol. 28, p. 38, 2006 (Chinese). View at Google Scholar
  19. J. Yin, Z. Gao, D. Liu, Z. Liu, and J. Ye, “Berberine improves glucose metabolism through induction of glycolysis,” American Journal of Physiology, vol. 294, no. 1, pp. E148–E156, 2008. View at Publisher · View at Google Scholar
  20. J. Yin, R. Hu, M. Chen et al., “Effects of berberine on glucose metabolism in vitro,” Metabolism, vol. 51, no. 11, pp. 1439–1443, 2002. View at Google Scholar
  21. Y. S. Lee, W. S. Kim, K. H. Kim et al., “Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states,” Diabetes, vol. 55, no. 8, pp. 2256–2264, 2006. View at Publisher · View at Google Scholar
  22. P. Yi, F.-E. Lu, L.-J. Xu, G. Chen, H. Dong, and K.-F. Wang, “Berberine reverses free-fatty-acid-induced insulin resistance in 3T3-L1 adipocytes through targeting IKKβ,” World Journal of Gastroenterology, vol. 14, no. 6, pp. 876–883, 2008. View at Publisher · View at Google Scholar
  23. Z. Gao, S. Leng, F. Lu, M. Xie, L. Xu, and K. Wang, “Effect of berberine on expression of hepatocyte nuclear factor-4α in rats with fructose-induced insulin resistance,” Journal of Huazhong University of Science and Technology, vol. 28, no. 3, pp. 261–265, 2008. View at Publisher · View at Google Scholar