Islet Specific Wnt Activation in Human Type II Diabetes
Figure 6
Wnt signaling in high-fat fed mice. In normal mouse pancreas, β-catenin (green in (a) and (b))
is expressed in islets as identified by somatostatin (red in (a)) and colocalizes with insulin (red in
(c)). c-myc (red in (d) and (e)) was not expressed in islets of normal mice (marked by dotted lines and
glucagon in green in (d)) but was induced in islets and some ducts of high-fat fed mice (islets
marked by glucagon in green). C-myc expression is quantitated in (f). At 12 weeks, the time of
analysis, high-fat mice were obese (g), and nondiabetic but mildly glucose-intolerant as
measured by IPGTT (h). Number of normal mice = 3 and number of high-fat mice = 4 for (f), (g), and (h).
Error bars = mean +/−s.e.m. *. Scale bars: 100 m.
