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Experimental Diabetes Research
Volume 2008, Article ID 819123, 2 pages
Review Article

Fulminant Type 1 Diabetes as a Model of Nature to Explore the Role of C-Peptide

First Department of Internal Medicine, Osaka Medical College, 2-7 Daigaku-Machi, Takatsuki 569-8686, Japan

Received 27 November 2007; Accepted 26 February 2008

Academic Editor: Thomas Forst

Copyright © 2008 Yuko Murase-Mishiba et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Patients with fulminant type 1 diabetes almost completely lack C-peptide even soon after the onset of the disease, and the deficiency continues for the rest of their life. Thus, fulminant type 1 diabetes could serve as a good model of nature to explore the physiological role of C-peptide. For example, patients with fulminant type 1 diabetes have diabetic chronic complications more frequently than those with classical autoimmune type 1 diabetes 5 years after the onset of diabetes, and the higher prevalence could be partly attributable to the complete lack of C-peptide in fulminant type 1 diabetes.