Structural and Ultrastructural Analysis of Cerebral Cortex, Cerebellum, and Hypothalamus from Diabetic Rats

Figure 3

Structural alterations in diabetes. (a) Normal cerebral pyramidal cells (arrows). (b) Vacuolization of pyramidal cells in diabetes (arrows) and a probably apoptotic cell (crossed arrow). (c) Purkinje cells (arrows) in normal cerebellar section. (d) Vacuolization of Purkinje cells (arrows); note also vacuolization of granular layer cells. (e) Vacuolization of neuropil and cells (arrows) in cerebellar molecular layer. (f) Vacuolization of dark cells (arrows) and neuropil in hypothalamus of diabetic rat. GL: granular layer; ML: molecular layer. Magnification: ×1000 (a)–(d); ×400 ((e) and (f)). There is toluidine blue staining.

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